{"id":482,"date":"2021-11-28T13:03:25","date_gmt":"2021-11-28T12:03:25","guid":{"rendered":"https:\/\/cerenef.org\/?page_id=482"},"modified":"2025-10-04T15:22:58","modified_gmt":"2025-10-04T13:22:58","slug":"recherche-neurofibromatoses-centre-de-reference","status":"publish","type":"post","link":"https:\/\/cerenef.org\/en\/recherche-neurofibromatoses-centre-de-reference\/","title":{"rendered":"Within the referral centre"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"482\" class=\"elementor elementor-482\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-026e688 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"026e688\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8f6e8f7\" data-id=\"8f6e8f7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2960b52 elementor-widget elementor-widget-image\" data-id=\"2960b52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/cerenef.org\/wp-content\/uploads\/2022\/01\/recherche-mondor.jpg\" title=\"CERENEF\" alt=\"CERENEF\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1f1fda37 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1f1fda37\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70c9f5ef\" data-id=\"70c9f5ef\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5ee11a3a elementor-widget elementor-widget-text-editor\" data-id=\"5ee11a3a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The referral centre has developed projects in the following research areas:<\/p><ul><li>Therapeutic trials: Pierre Wolkenstein (Henri-Mondor Hospital) and Michel Kalamarides (Piti\u00e9-Salp\u00eatri\u00e8re Hospital).<\/li><li>Surgical techniques: Michel Kalamarides, Laurent Lantieri (Georges Pompidou European Hospital) and Philippe Decq (Beaujon Hospital).<\/li><li>Animal models: Pierre Wolkenstein, Piotr Topilko (Henri-Mondor Hospital), Michel Kalamarides and Marcello Giovannini (San Paolo Hospital, Milan).<\/li><li>Molecular biology: Beno\u00eet Funalot from the Genetics Department (Henri-Mondor Hospital) as well as Michel Vidaud, \u00c9ric Pasmant, and Dominique Vidaud from the Cochin Institute, Inserm team (genomics and epigenetics of rare tumours).<\/li><li>Clinical epidemiology: Pierre Wolkenstein and \u00c9milie Sbidian (Henri-Mondor Hospital).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6c30f58 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6c30f58\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1e2a8e6\" data-id=\"1e2a8e6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e91cee9 elementor-widget elementor-widget-heading\" data-id=\"e91cee9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Epidemiologic research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f97c8f2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f97c8f2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f313567\" data-id=\"f313567\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d3c870 elementor-widget elementor-widget-toggle\" data-id=\"8d3c870\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1481\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1481\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Epidemiology in Dermatology and Evaluation of therapeutics - EpiDermE<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1481\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1481\"><p>The referral centre works in collaboration with the EpiDermE team.<\/p><p>Led by Pr. \u00c9milie Sbidian, EpiDermE (Epidemiology in Dermatology and Evaluation of therapeutics), is a pharmaco-epidemiology research team whose two main axes are:<\/p><ul><li>The benefit\/risk assessment of the therapeutics used in chronic inflammatory pathologies.<\/li><li>Medication errors and serious skin adverse effects of therapeutics.<\/li><\/ul><p><a href=\"https:\/\/team-epiderme.com\/\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1482\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1482\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">ComPare<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1482\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1482\"><p>If you are being followed for neurofibromatosis type 1, you can participate in epidemiological research. Your experience and testimonial are of crucial importance to enable researchers and doctors to improve your quality of life and your treatments.<\/p><p>By sharing your experience, you will help to accelerate medical research on neurofibromatosis type 1. Similar to other patients with different chronic diseases, you can then participate in the ComPaRe online cohort.<\/p><p><a href=\"https:\/\/compare.aphp.fr\/participer\/je-participe.html\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-42e581d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"42e581d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-56058d8\" data-id=\"56058d8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ad71700 elementor-widget elementor-widget-heading\" data-id=\"ad71700\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Fundamental research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-02a40c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"02a40c9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8fdac48\" data-id=\"8fdac48\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-66ce1a5 elementor-widget elementor-widget-toggle\" data-id=\"66ce1a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1071\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1071\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">A unique murine animal model<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1071\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1071\"><p>Neurofibromatosis type 1 (NF1), one of the most common genodermatosis, is defined as the association of pigmented lesions (\"caf\u00e9-au-lait\" macules [CALMs] and lentigines), neurofibromas (cutaneous [NFc] and plexiform [NFp]), and ophthalmological and bone abnormalities: <a href=\"https:\/\/cerenef.org\/en\/comprendre-les-neurofibromatoses\/\" target=\"_blank\" rel=\"noopener\">NF1 diagnostic criteria<\/a>.<\/p><p>It is linked to a mono-allelic mutation in the NF1 gene and the loss of heterozygosity due to its complications. Several animal models have allowed to explore its pathophysiology without ever reproducing its overall phenotype.<\/p><p><a href=\"https:\/\/imrb.inserm.fr\/equipes\/n-ortonne\/\" target=\"_blank\" rel=\"noopener\">Professor Piotr Topilko's Inserm team<\/a> has developed a unique murine model that reproduces the human one.<\/p><p>The mutant murine line (Nf1-KO) was obtained by bi-allelic inactivation of NF1 in cells that express the Prss56 gene. In the peripheral nervous system, the expression of Prss56 is limited to the frontier capsule (Fc) cells present during embryonic development at the entry and exit points of sensory and motor nerves.<\/p><p>We have shown that Fc cells give rise to Schwann cells that colonise the roots of nerves and then migrate along nerves into cutaneous nerve endings, which are the regions where patients' neurofibromas (NF) are located. Prss56 is also expressed in other structures affected by NF1: appendicular skeletal bone, eye, and brain.<\/p><p>Heterozygous NF1 bats have no symptoms. The loss of heterozygosity in NF1-KO results in a phenotype comparable to that of humans.<\/p><p>All mice develop paraspinal and subcutaneous NFc (100% at 1 year) and most of them NFp (60% at 5 months). The cellular composition of murine NF reproduces that of human NF. In addition, 70% of NFp spontaneously turns into malignant tumours of the nerve sheaths.<\/p><p>Finally, as in humans, mice systematically develop the following disorders either spontaneously or induced: CALMs, bone lesions (pseudarthrosis, spinal or craniofacial deformities), eye lesions (hamartomas), and abnormal oligodendrogenesis. The latter could be at the origin of the learning difficulties observed in children with NF1.<\/p><p>To our knowledge, this is the only animal model with the majority of manifestations associated with NF1 and thus meeting the diagnostic criteria for NF1.<\/p><p>Its exploration allows us:<\/p><ul><li>Study the mechanisms that govern the development of NF and their malignant transformation.<\/li><li>Initiate therapeutic trials to prevent or block their development in mice.<\/li><\/ul><p>These advances provide a robust and necessary basis for the future trials to develop innovative treatments for patients with NF.<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-505 size-full\" title=\"Professor Piotr Topilko and his Inserm team\" src=\"https:\/\/cerenef.org\/wp-content\/uploads\/2021\/11\/Equipe-Piotr-T-2.jpg\" alt=\"Piotr Topilko et son \u00e9quipe Inserm\" width=\"1500\" height=\"667\" srcset=\"https:\/\/cerenef.org\/wp-content\/uploads\/2021\/11\/Equipe-Piotr-T-2.jpg 1500w, https:\/\/cerenef.org\/wp-content\/uploads\/2021\/11\/Equipe-Piotr-T-2-300x133.jpg 300w, https:\/\/cerenef.org\/wp-content\/uploads\/2021\/11\/Equipe-Piotr-T-2-1024x455.jpg 1024w, https:\/\/cerenef.org\/wp-content\/uploads\/2021\/11\/Equipe-Piotr-T-2-768x342.jpg 768w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/p><p style=\"text-align: center; margin-top: 15px;\">Professor Piotr Topilko and his Inserm team<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1072\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1072\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Publications<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1072\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1072\"><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40684195\/\" target=\"_blank\" rel=\"noopener\">Development of Cutaneous Neurofibromas in Neurofibromatosis Type\u00a0<\/a><br \/><em>Pulh P, Coulpier F, Onfroy A, Oubrou L, Zhang W, Toledano L, Abou Zougheib E, Fertitta L, Wolkenstein P and Topilko P<\/em><br \/><em>Unraveling the Acta Neuropathologica Communications. 2025 Jul 19;13(1):158<\/em><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37331503\/\" target=\"_blank\" rel=\"noopener\">Topical delivery of MEK inhibitor binimetinib prevents the development of cutaneous neurofibromas in Neurofibromatosis type 1 mutant mice<\/a><br \/><em>Coulpier F, Pulh P, Oubrou L, Naudet J, Fertitta L, Gregoire JM, Bocquet A, Schmitt AM, Wolkenstein P, Radomska KJ, Topilko P.<\/em><br \/><em>Transl Res. 2023 Jun 16:S1931-5244(23)00105-6. doi: 10.1016\/j.trsl.2023.06.003. Online ahead of print.<\/em><br \/><em>PMID: 37331503<\/em><\/p><p><a class=\"ox-cb4c897a66-docsum-title\" tabindex=\"9999\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30348676\/\" target=\"_blank\" rel=\"noopener\">Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with <em>Nf1<\/em> Knockout in Boundary Cap Cells<\/a><br \/><em>Radomska KJ, Coulpier F, Gresset A, Schmitt A, Debbiche A, Lemoine S, Wolkenstein P, Vallat JM, Charnay P, Topilko P.<\/em><br \/><em>Cancer Discov. 2019 Jan;9(1):130-147. doi: 10.1158\/2159-8290.CD-18-0156. Epub 2018 Oct 22.<\/em><br \/><em><span class=\"ox-cb4c897a66-citation-part\">PMID: <span class=\"ox-cb4c897a66-docsum-pmid\">30348676<\/span><\/span><\/em><\/p><p><a class=\"ox-95ddb71348-docsum-title\" tabindex=\"9999\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29174469\/\" target=\"_blank\" rel=\"noopener\">Boundary cap cells in development and disease<\/a><br \/><em>Radomska KJ, Topilko P.<\/em><br \/><em>Curr Opin Neurobiol. 2017 Dec;47:209-215. doi: 10.1016\/j.conb.2017.11.003. Epub 2017 Nov 22.<\/em><br \/><em><span class=\"ox-95ddb71348-citation-part\">PMID: <span class=\"ox-95ddb71348-docsum-pmid\">29174469<\/span><\/span> <span class=\"ox-95ddb71348-publication-type ox-95ddb71348-spaced-citation-item ox-95ddb71348-citation-part\">Review.<\/span><\/em><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1073\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1073\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Bibliographic references<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1073\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1073\"><ol><li>Radomska K, Coulpier F, Gresset A, Schmitt A, Debbiche A, Wolkenstein P, Vallat J-M, Charnay P, Topilko P. Cellular origin, tumor progression and pathogenic mechanisms of cutaneous neurofibromas revealed by mice with Nf1 knock out in boundary cap cells. Cancer Discovery 2019.<\/li><li>Radomska KJ, Topilko P. Boundary cap cells in development and disease. Curr Opin Neurobiology 2017;47:209-215.<\/li><li>Gresset A, Coulpier F, Gerschenfeld G, Jourdon A, Matesic G, Richard L, Vallat JM, Charnay P, Topilko P. Boundary Caps Give Rise to Neurogenic Stem Cells and Terminal Glia in the Skin. Stem Cell Reports. 2015;5(2):278\u201390.<\/li><\/ol><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5d3d00e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5d3d00e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-838c292\" data-id=\"838c292\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b13280c elementor-widget elementor-widget-heading\" data-id=\"b13280c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Clinical research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0deebd5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0deebd5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-45a4ea2\" data-id=\"45a4ea2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-22df8b0 elementor-widget elementor-widget-text-editor\" data-id=\"22df8b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Several clinical research activities are also carried out in collaboration with the Mondor GHU clinical investigation centre, including the realisation of the following Hospital Clinical Research Protocols (Protocoles Hospitaliers de Recherche Clinique, PHRC) and therapeutic trials:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ceaa04 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ceaa04\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-50b050e\" data-id=\"50b050e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a06756b elementor-widget elementor-widget-toggle\" data-id=\"a06756b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1681\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1681\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">PHRC 2002 - NF1<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1681\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1681\"><p>Study of the expression of neurofibromatosis 1 with establishment of a phenotype\/genotype database. Thus, 1017 patients were enrolled this multicentre study from March 2003 to March 2006.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1682\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1682\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">PHRC 2005 - EvoNF<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1682\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1682\"><p>Patients at risk of evolution during neurofibromatosis 1 with a comparative phenotypic, genotypic, and proteomic study within a cohort. Thus, 219 patients were enrolled in 3 centres from June 2007 to January 2008.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1683\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1683\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">PHRC 2010\u00a0- GenModif<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1683\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1683\"><p>Study of the expression of neurofibromatosis 1 with identification of modifying genes. Thus, 475 patients were enrolled in this multicentre study from June 2012 to November 2013.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1684\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-1684\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">NFitor study<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1684\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-1684\"><p>Multicentre, phase IIa, open-label trial evaluating RAD001 (everolimus) monotherapy during neurofibromatosis 1 for the treatment of inoperable internal plexiform neurofibromas. Inclusion of 23 patients across 3 centres from April 2011 to June 2014.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1685\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-1685\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">OsteoNF study<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1685\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-1685\"><p>Predictive risk factors for osteoporosis in neurofibromatosis 1. Single-centre enrolment of 60 patients from November 2014 to March 2016.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1686\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-1686\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Associated references<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1686\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-1686\"><ol><li>Sabbagh A, PasmantE, Laurendeau I, Parfait B, Barbarot S, Guillot B, et al. Unravelling the genetic basis of variable clinical expression in neurofibromatosis 1. Hum Mol Genet. 2009;18(15):2768\u201178.<\/li><li>Wolkenstein P, Rodriguez D, Ferkal S, Gravier H, Buret V, Algans N, et al. Impact of neurofibromatosis 1 upon quality of life in childhood: a cross-sectional study of 79 cases. Br J Dermatol. 2009;160(4):844\u20118.<\/li><li>Pasmant E, Sabbagh A, Spurlock G, Laurendeau I, Grillo E, Hamel M-J, et al. NF1 microdeletions in neurofibromatosis type 1: from genotype to phenotype. Hum Mutat. 2010;31(6):E1506-1518.<\/li><li>Sbidian E, Wolkenstein P, Valeyrie-Allanore L, Rodriguez D, Hadj-Rabia S, Ferkal S, et al. NF-1Score: a prediction score for internal neurofibromas in neurofibromatosis-1. J Invest Dermatol. 2010;130(9):2173\u20118.<\/li><li>Sbidian E, Bastuji-Garin S, Valeyrie-Allanore L, Ferkal S, Lefaucheur JP, Drouet A, et al. At-risk phenotype of neurofibromatose-1 patients: a multicentre case-control study. Orphanet J Rare Dis. 2011;6:51.<\/li><li>Pasmant E, Sabbagh A, Masliah-Planchon J, Ortonne N, Laurendeau I, Melin L, et al. Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1. J Natl Cancer Inst. 2011;103(22):1713\u201122.<\/li><li>Sabbagh A, Pasmant E, Imbard A, Luscan A, Soares M, Blanch\u00e9 H, et al. NF1 molecular characterization and neurofibromatosis type I genotype-phenotype correlation: the French experience. Hum Mutat. 2013;34(11):1510\u20118.<\/li><li>Imbard A, Pasmant E, Sabbagh A, Luscan A, Soares M, Goussard P, et al. NF1 single and multi-exons copy number variations in neurofibromatosis type 1. J Hum Genet. 2015;60(4):221\u20114.<\/li><li>Zehou O, Ferkal S, Brugieres P, Barbarot S, Bastuji-Garin S, Combemale P, et al. Absence of Efficacy of Everolimus in Neurofibromatosis 1-Related Plexiform Neurofibromas: Results from a Phase 2a Trial. J Invest Dermatol. 2019;139(3):718\u201120.<\/li><li>Pacot L, Vidaud D, Sabbagh A, Laurendeau I, Briand-Suleau A, Coustier A, et al. Severe Phenotype in Patients with Large Deletions of NF1. Cancers. 2021;13(12):2963.<\/li><li>Jalabert M, Ferkal S, Souberbielle J-C, Sbidian E, Mageau A, Eymard F, et al. Bone Status According to Neurofibromatosis Type 1 Phenotype: A Descriptive Study of 60 Women in France. Calcif Tissue Int. 2021;108(6):738\u201145.<\/li><\/ol><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db746a1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"db746a1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-711e33c\" data-id=\"711e33c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aece8a1 elementor-widget elementor-widget-heading\" data-id=\"aece8a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Rare dermatologic diseases branch and French Society of Dermatology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9c99bad elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9c99bad\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fc2b538\" data-id=\"fc2b538\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9dbdc5a elementor-widget elementor-widget-text-editor\" data-id=\"9dbdc5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In the dermatology field, learned societies and teachers' training colleges also contribute to the research in the rare diseases arena.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-17d8131 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"17d8131\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3d2f580\" data-id=\"3d2f580\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8cdc210 elementor-widget elementor-widget-toggle\" data-id=\"8cdc210\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1471\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1471\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">College of Teachers in Dermatology of France (Coll\u00e8ge des Enseignants en Dermatologie de France, CEDEF)<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1471\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1471\"><p>President: Pr. Marie-Aleth Richard.<\/p><p><a href=\"https:\/\/cedef.org\/\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1472\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1472\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Rare dermatologic diseases branch (FIli\u00e8re sant\u00e9 Maladies RAres Dermatologiques, FIMARAD)<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1472\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1472\"><p>Coordinator: Pr. Christine Bodemer.<\/p><p><a href=\"https:\/\/fimarad.org\/\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1473\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1473\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-caret-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-caret-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">French Society of Dermatology (Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatology, SFD)<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1473\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1473\"><p>President: Pr. Ga\u00eblle Qu\u00e9reux-Baumgartner<\/p><p><a href=\"https:\/\/www.sfdermato.org\/\" target=\"_blank\" rel=\"noopener\">Website<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2e6daee elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2e6daee\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d17d112\" data-id=\"d17d112\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f5b5c49 elementor-widget elementor-widget-heading\" data-id=\"f5b5c49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">HORIZON NF1<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1fe1592 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1fe1592\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-55fd622\" data-id=\"55fd622\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1ea942d elementor-widget elementor-widget-text-editor\" data-id=\"1ea942d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Horizon is a magazine dedicated to sharing innovative initiatives by expert centers to improve the care and treatment of patients with rare diseases. It is produced on the initiative of RARE \u00e0 l'\u00e9coute, in partnership with the relevant rare disease health network. It is distributed in the form of copies sent directly to the reference and competence centers involved, and via a digital version available here, on the RARE \u00e0 l'\u00e9coute website.\n\nTranslated with DeepL.com (free version)<\/p><p>Horizon NF1, presents innovative actions to improve support and care for patients with neurofibromatosis type 1 (NF1). It is produced in partnership withcCERENEF.<\/p><p><a href=\"https:\/\/rarealecoute.com\/horizon-nf1\/\" target=\"_blank\" rel=\"noopener\">Consult the HORIZON NF1 magazines<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Dans le domaine de la recherche le centre de r\u00e9f\u00e9rence a d\u00e9velopp\u00e9 des projets dans les th\u00e9matiques suivantes : Essais th\u00e9rapeutiques : Pierre Wolkenstein (h\u00f4pital Henri-Mondor) et Michel Kalamarides (h\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re). Technique chirurgicale : Michel Kalamarides, Laurent Lantieri (h\u00f4pital Europ\u00e9en Georges Pompidou) et Philippe Decq (h\u00f4pital Beaujon). Mod\u00e8les animaux : Pierre Wolkenstein, Piotr Topilko (h\u00f4pital&hellip;&nbsp;<\/p>\n<div class=\"read-more-wrapper\"><a href=\"https:\/\/cerenef.org\/en\/recherche-neurofibromatoses-centre-de-reference\/\" class=\"button button-secondary\" rel=\"bookmark\">\u279c Read more<span class=\"screen-reader-text\">Within the referral centre<\/span><\/a><\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","neve_meta_reading_time":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-482","post","type-post","status-publish","format-standard","hentry","category-la-recherche"],"_links":{"self":[{"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/posts\/482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/comments?post=482"}],"version-history":[{"count":9,"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/posts\/482\/revisions"}],"predecessor-version":[{"id":4185,"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/posts\/482\/revisions\/4185"}],"wp:attachment":[{"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/media?parent=482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/categories?post=482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cerenef.org\/en\/wp-json\/wp\/v2\/tags?post=482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}