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Fundamental research


Fundamental research is the branch of science that allows the analysis and understanding of events, as well astheir causes and consequences. It is based on experiments and theories. Experiments can be performed in vivo (in humans or animals), in vitro (on cultured cells), or ex vivo (e.g., biological tests).

The ultimate goal of this research is the development of new, safe, and effective treatments in humans.

In the field of neurofibromatosis type 1 (NF1), Professor Piotr Topilko's Inserm at the IMRB of the Henri Mondor Hospital has developed a unique animal model reproducing NF1. This model allows us:

  • To study the mechanisms that govern the development of neurofibromas and their malignant transformation.
  • To initiate therapeutic trials to prevent or block their development.

These advances provide a robust and necessary basis for the future development of trials to develop innovative treatments in humans.

For more information and to participate more actively in this research, please consult your NF1 referring physician.